RETIN-A

Using directions

While using Retin-A, Avita, or Renova, keep exposure to sunlight, including sunlamps, to a minimum. If you have a sunburn, do not use the medication until you have fully recovered. Use of sunscreen products (at least SPF 15) and protective clothing overtreated areas is recommended when exposure to the sun cannot be avoided. Weather extremes, such as wind and cold, may be irritating and should also be avoided while using these products.

Retin-A and Avita should be applied once a day, at bedtime, tothe skin where acne appears, using enough to lightly cover the affected area. The liquid form may be applied using a fingertip, gauze pad, or cotton swab. If you use gauze or cotton, avoid over saturation, which might cause the liquid to run into areas where treatment is not intended.

Renova is also applied once daily at bedtime. Use only enough to lightly cover the affected area. Before you use Renova, wash your facewith a mild soap, pat your skin dry, and wait 20 to 30 minutes. Then apply a dab of Renova cream the size of a pea and spread it lightly over your face, avoiding your eyes, ears, nostrils, mouth, and open wounds.

You may use cosmetics while being treated with these products;however, you should thoroughly cleanse the areas to be treated before applying the medication.

If your skin becomes too dry, you may want to use petroleum jelly or another emollient during the day.

If there is no immediate improvement, or new blemishes appear, don't get discouraged; it takes weeks for the medicine to take effect. Continue applying the prescribed amount. (Do not increase the dosage; it may irritateyour skin.)

Do not stop treatment when improvement finally occurs. You must continue therapy to maintain the beneficial effect.

If you miss a dose... Resume your regular schedule the next day.
Store at ordinary room temperature. Do not freeze Renova.

If you are sensitive to or have ever had an allergic reaction to either of these products, avoid using them.
The safety and effectiveness of long-term use of Retin-A in the treatment of disorders other than acne have not been established.
The safety and effectiveness of Renova have not been established in children under age 18, adults over age 50, and people with heavily pigmented skin, nor in periods of greater than 48 weeks of daily use.

Cautions

Be sure to keep these products away from the eyes, mouth, angles of the nose, and mucous membranes.

The medication may cause a brief feeling of warmth or slightstinging when applied. If it causes an abnormal irritation, redness, blistering, or peeling of the skin, notify your doctor. He may suggest that you use the medication less frequently, discontinue use temporarily, or discontinue use altogether. If a severe sensitivity reaction or chemical irritation occurs, you will probably need to stop using the drug.

If you have eczema (skin inflammation consisting of itching and smallblisters that ooze and crust over) or other chronic skin conditions, use these products with extreme caution, as they may cause severe irritation.

During the early weeks of acne therapy, a worsening of the condition may occur due to the action of Avita or Retin-A on deep, previously unseen areas of inflammation. This isnot a reason to discontinue therapy, but do notify your doctor if it occurs.

Retin-A gel and Avita are flammable and should be kept away from heat and flame.

Renova will not eliminate wrinkles, repair damage done by the sun, or reverse the aging process. After you stop using Renova, it is best to continue using a sunscreen and avoiding the sun.

Possible side effects

If you have sensitive skin, the use of Avita orRetin-A may cause your skin to become excessively red, puffy, blistered, or crusted. If this happens, notify your doctor, who may recommend that you discontinue the medication until your skin returns to normal, or adjust the medication to a level that you can tolerate.

An unusual darkening of the skin or lack of color of the skin may occur temporarily with repeated application of Avita or Retin-A.

Side effects of Renova are generally not severe and may include burning,dry skin, itching, peeling, redness, and stinging.

If you are pregnant or plan to become pregnant, do not use these products. It is not known whether the drug appears in breast milk. Use with caution when breastfeeding

Possible food and drug interactions

If these medications are used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Avita or Retin-A withthe following:

Preparations containing benzoyl peroxide, such as Benzac AC Wash 5, Benzshave Desquam-E, PanOxyl
Preparations containing sulfur (ointments and other preparations used to treat skin disorders and infections)
Resorcinol (a drug, used in ointments to treat acne, that causes skin to peel)
Salicylic acid (a drug that kills bacteria and fungi and causes skin to peel)
""Resting"" your skin is recommended between use of the above preparations and treatment with Avita or Retin-A.
Do not use Renova if you are taking other drugs that increase sensitivity to sunlight. These include:
Certain antibiotics, including Cipro, Noroxin, and tetracycline
Major tranquilizers such as Thorazine and Mellaril
Sulfa drugs such as Bactrim and Septra
Thiazide drugs (water pills) such as Diuril and HydroDIURIL

Caution should be exercised when using Avita, Retin-A, or Renova in combination with other topical medications, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, products with high concentrations of alcohol, astringents, spices, or lime (especiallythe peel), permanent wave solutions, electrolysis, hair depilatories or waxes, or other preparations that may dryor irritate the skin.

Dosage instructions

RETIN-A AND AVITA

Apply once a day at bedtime.

You should begin to notice results after 2 to 3 weeks of treatment. More than 6 or 7 weeks of treatment are needed before consistent beneficial effects appear.

Once acne has responded satisfactorily, it may be possible to maintain the improvement with less frequent applications or other dosage forms. However,any change in formulation, drug concentration, or dose frequency should be closely monitored by your doctor to determine your tolerance and response.

RENOVA

Apply just enough to lightly cover the affected area once daily at bedtime. Do not apply more than the recommended amount; it will not improve results and may cause increased discomfort. You will see the most improvement during the first 24 weeks of therapy. After that, Renova will simply maintainthe improvement. When therapy is stopped, the improvement will gradually diminish.

Applying Avita, Retin-A or Renova excessively will not produce faster or better results, and marked redness, peeling, or discomfort could occur.

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